What is the endocannabinoid system?

What is the Endocannabinoid System and What Does the ECS Do?

Interested in using CBD oil to promote balance but want to know more about how CBD works? Here we explore the role of the endocannabinoid system in CBD’s benefits.

CBD oil has become a popular wellness product, being used by consumers across the U.S. and around the world. But do you know how CBD works in your body?

Naturally occurring cannabinoids like cannabidiol (CBD) from hemp and other cannabis plants interact with your body’s endocannabinoid system to trigger their beneficial effects. When derived from plants, cannabinoids are classified as phytocannabinoids. These cannabinoids are present in CBD oil and are absorbed by the body once these CBD oil products are used.

The endocannabinoid system (also referred to as the ECS or the EC system) is responsible for regulating homeostasis in our body through the communication between cells. Until the recent discovery of the endocannabinoid system, it remained an unknown part of the human body’s functions, despite its role in balancing the human body.

Named for the plant that inspired its discovery, the endocannabinoid system is a key to promoting overall health and wellness, but its role in regulating the body is only just becoming understood. Keep reading to learn more about the role of the endocannabinoid system in the benefits of CBD.

Discovery of the Endocannabinoid System

Extractions of the cannabis plant were once widely used for a number of natural purposes across many of the world’s cultures up until early in the 20th century.

hemp endocannabinoid system

However, following the practical prohibition of the cannabis plant in 1937 by the U.S. government for fear of abuse of its psychoactive properties, the study of cannabis was eliminated, stalling the progress of our understanding of the endocannabinoid system and its role in the body.

For nearly 50 years, marijuana was labeled as illicit in the minds of Americans, which directly affected our relationship with hemp as well. This also made it difficult for researchers, especially in the U.S., to properly study cannabinoids and the endocannabinoid system.

In the early 1990’s, scientists were able to define endocannabinoids and their interactions with the body. Researcher Lisa Matsuda announced that her team at the National Institute of Mental Health had been the first to identify a THC sensitive receptor in the brains of lab rats, further defining the role of the ECS.

This discovery was touted as a breakthrough in cannabinoid research. However, the journey to discover the endocannabinoid system and cannabinoid receptors in the human body started more than a century earlier with the discovery of the first cannabinoid.

In 1895, researchers became the first to isolate and identify a cannabis derived cannabinoid, cannabinol (CBN). Over the next 70 years, researchers identified more cannabinoids, including researchers who identified and isolated CBD in 1940 and others who isolated and identified tetrahydrocannabinol (THC) in 1964. Following these monumental breakthroughs, researchers spent decades exploring these and other cannabinoids, their properties, and their potential natural benefits.

endocannabinoid system explanation

It was in the early and mid-1990s when renowned cannabinoid researcher Raphael Mechoulam and colleagues officially discovered the endocannabinoid system. It happened after he and his team were able to locate and identify two of the body’s naturally produced major endocannabinoids: anandamide and 2-arachidonoylglycerol, or 2-AG. This was followed by Matsuda’s team discovering the cannabinoid receptor.

Since then, scientists have labored to learn as much as they can about the endocannabinoid system, our naturally occurring cannabinoids, and the ways that using cannabis alters this balance, publishing over 20,000 scientific studies referencing cannabinoids in just the last two decades.

What is the Endocannabinoid System?

The endocannabinoid system is made up of these integrated mechanisms:

  • Enzymes responsible for creating and destroying cannabinoids
  • Receptor sites on cells to receive cannabinoids
  • Endocannabinoids themselves (cannabinoid-like compounds that are naturally produced by the human body)

These mechanisms are predominantly responsible for communication within the body to best regulate various biological responses to keep the body in homeostasis.

endocannabinoid system definition

One of the prime questions raised in these early studies was whether or not the body produces its own natural equivalents to the previously discovered compounds called phytocannabinoids, like THC and CBD, found in the cannabis plant.

The answer turned out to be “yes” – in the form of the endocannabinoids anandamide and 2-AG, which are the two prominent analogs to THC and CBD. With the understanding that the cannabinoid system allows humans to create our own cannabinoids, the door to deconstructing the purpose of the endocannabinoid system was opened.

Endocannabinoids As a Response to Imbalance

Endocannabinoids are created in response to needs within the larger physiological system and are largely understood to be used for the body’s regulatory functions. Acting backward on presynaptic cells, they control the volume at which communicating signals are sent. It is in this way that endocannabinoids affect the duration and intensity of the wide range of physiological processes under their control.

How Does the Endocannabinoid System Work?

Whenever there are deviations from homeostasis (balance) in the body’s functions, the endocannabinoid system is activated and begins to respond accordingly by synthesizing endocannabinoids, which act as neurotransmitters.

When the body creates endocannabinoid neurotransmitters, they are picked up by specialized cannabinoid receptors, which sit on the surface of cells. These receptors are found in a wide range of physiological regions.

Like a key fits into a lock, endocannabinoids interact with these receptors and transmit information about changing conditions to kick-start a response, with the goal of helping the body achieve homeostasis, or equilibrium, within the body, despite outside influences.

The endocannabinoid system’s receptor sites include CB1 and CB2 receptor variants, which respond differently to various cannabinoids. Some cells can even contain both types of receptors, each responsible for a different function.

There are two major endocannabinoids produced by the body – 2-arachidonoylglycerol (2-AG) and Anandamide (AEA).

2-AG is considered a full agonist of both CB1 and CB2 receptors. This means that it binds with, and fits well inside, both receptors to activate them to stimulate a physiological response.

Anandamide is considered a partial agonist of both receptors, because, while it binds with and activates the receptors, it doesn’t fit as well inside them and subsequently doesn’t trigger such a powerful physiological response.

Once the function that had deviated from homeostasis returns to equilibrium and the endocannabinoids are no longer needed, the third piece of the system – the metabolic enzymes – breaks down and degrades these endocannabinoids to shut off their signal.

Fatty acid amide hydrolase (FAAH) degrades Anandamide, and monoacylglycerol lipase (MAGL) breaks down 2-AG. By eliminating the endocannabinoids, the endocannabinoid system “turns off” the molecular signals and ends whatever physiological activity it had stimulated.

How Do Cannabis Derived Cannabinoids Work with the Endocannabinoid System?

As scientists learn more about the endocannabinoid system, they also explore the potential role the cannabis derived cannabinoids like CBD, THC, CBN, and more could play in supporting the system.

Science evidences a strong relationship between the endocannabinoid system and CBD. Cannabinoids, like those found in CBD oils and CBD isolates, mimic the behavior of endocannabinoids and interact with the cannabinoid receptors to augment the endocannabinoid system. As the cannabinoids interact with the cannabinoid receptors, they stimulate various physiological responses.

THC, the well recognized psychoactive compound found in marijuana, activates receptors to elicit a chemical response. It is considered an agonist of both CB1 and CB2 receptors because it directly binds to the receptors and activates them. THC tends to favor CB1 receptors because it fits very well inside them and therefore is able to stimulate a strong physiological reaction.

When THC reacts with CB1 receptors, this is what causes the well known “high” feeling from marijuana. THC also directly activates CB2 receptors, but is considered a partial agonist and therefore doesn’t elicit such a strong physiological response.

CBD causes chemical changes by blocking receptors. It tends to have low affinity for both CB1 and CB2 receptors, and instead acts as an indirect antagonist of agonists. This means that CBD sits imperfectly inside the receptors, not activating them but preventing other chemical messengers like THC from binding to them.

Should I Add Cannabinoids to My Body?

As we continue to learn more about the endocannabinoid system, we will also learn about the potential for the scope of active compounds from cannabis (like THC, CBD, and CBN).

One theory about the endocannabinoid system is the proposed endocannabinoid deficiency syndrome, or CECD, which speculates that, for some people, the body does not generate enough endocannabinoids due to under stimulation of the system.

This concept, originally proposed by researcher E.B. Russo in 2004, further speculates that the endocannabinoid system deficiency could negatively affect your quality of life.

Phytocannabinoids, like the THC from cannabis or the concentrated CBD in hemp, obviously affect the endocannabinoid system. However, it has also been shown that non-intoxicating phytocannabinoids from other plants, and even other compounds like terpenes and flavonoids, are picked up by receptors in our endocannabinoid systems.

Because small doses of phytocannabinoids can encourage the body to create more naturally occurring endocannabinoids and their receptors, it may be possible to bolster the sensitivity of our native systems by using cannabinoids regularly.

Overall, significant research must still be done to better understand the impact of the endocannabinoid system on our overall health and how supporting our natural endocannabinoid production with plant based cannabinoids may play a significant therapeutic role in our health. However, extensive early studies show great potential for using this vital system to the benefit of patient health.

Learn More About Cannabinoids like CBD

Want to learn more about the endocannabinoid system, cannabinoids like CBD, and the benefits of using CBD daily? Visit our CBD Education page.

Ready to get started using CBD for yourself? Visit the HempMeds® online store today.


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